Alzheimer’s Precursors Founds at Earlier Age

Scientists studying Alzheimer’s disease are increasingly finding clues that the brain begins to deteriorate years before a person shows symptoms of dementia.

Now, research on a large extended family of 5,000 people in Colombia with a genetically driven form of Alzheimer’s has found evidence that the precursors of the disease begin even earlier than previously thought, and that this early brain deterioration occurs in more ways than has been documented before.

The studies, published this month in the journal Lancet Neurology, found that the brains of people destined to develop Alzheimer’s clearly show changes at least 20 years before they have any cognitive impairment. In the Colombian family, researchers saw these changes in people ages 18 to 26; on average, members of this family develop symptoms of mild cognitive impairment at 45 and of dementia at 53.

These brain changes occur earlier than the first signs of plaques made from a protein called beta amyloid or a-beta, a hallmark of Alzheimer’s. Researchers detected higher-than-normal levels of amyloid in the spinal fluid of these young adults. They found suggestions that memory-encoding parts of the brain were already working harder than in normal brains. And they identified indications that brain areas known to be affected by Alzheimer’s may be smaller than in those who do not have the Alzheimer’s gene.

“This is one of the most important pieces of direct evidence that individual persons have the disease and all the pathology many years before,” said Dr. Kaj Blennow, a professor in clinical neurochemistry at the University of Gothenburg in Sweden, who was not involved in the research.

Dr. Nick Fox, a neurologist at University College London, who was also not part of the research, said the findings suggested that “some of the things that we thought were more downstream may not be quite so downstream; they may be happening earlier.”

That, in turn, said Dr. Fox, who wrote a commentary about the findings in Lancet Neurology, could have implications for when and how to treat people, because “there may be targets to attack, whether it’s high levels of a-beta or whatever, when people are still functioning very well.”

The Colombian family suffers from a rare form of Alzheimer’s that is caused by a genetic mutation; it strikes about a third of its members in midlife. Because the family is so large and researchers can identify who will get the disease, studying the family provides an unusual opportunity to learn about Alzheimer’s causes and pathology.

Researchers, led by Dr. Eric Reiman of the Banner Alzheimer’s Institute in Phoenix, and in Colombia by Dr. Francisco Lopera, a neurologist at the University of Antioquia, recently received a grant from the National Institutes of Health to conduct a clinical trial to test a drug on family members before they develop symptoms, to see if early brain changes can be halted or slowed.

The studies in Lancet Neurology used several tests, including spinal taps, brain imaging and functional M.R.I.

“The prevailing theory has been that development of Alzheimer’s disease begins with the progressive accumulation of amyloid in the brain,” Dr. Reiman said. “This study suggests there are changes that are occurring before amyloid deposition.”

One possibility is that brain areas are already impaired. Another possibility, experts said, is that these brain differences may go back to the young developing brain.

“It is a genetic disease, and it’s not hard to imagine that your gene results in some differences in the way your brain is formed,” said Dr. Adam Fleisher, director of brain imaging at the Banner Institute and an author of the studies.

In one of the Lancet Neurology studies, researchers examined 44 relatives between ages 18 to 26. Twenty had the mutation that causes Alzheimer’s. The cerebrospinal fluid of those with the mutation contained more amyloid than that of relatives without it. This was striking because researchers know that when people develop amyloid plaques — whether they have early-onset or late-onset Alzheimer’s — amyloid levels in their spinal fluid are lower than normal. That is believed to be because the fluid form of amyloid gets absorbed into the plaque form, Dr. Reiman said.

So, the high level of amyloid fluid in the Colombian family supports a hypothesis about a difference between the beginning phases of genetic early-onset Alzheimer’s and the more common late-onset Alzheimer’s. The difference may be that early-onset Alzheimer’s involves an overproduction of amyloid, while late onset involves a problem clearing amyloid from the brain.

In another result, when the subjects performed a task matching names with faces, those with the mutation had greater activity in the hippocampus and parahippocampus, areas involved in memory. Dr. Reiman suggested this could mean that the pre-Alzheimer’s brain has to expend more effort to encode memories than a normal brain.

Researchers also found that the mutation carriers had less gray matter in areas that tend to shrink when people develop dementia. Dr. Fox emphasized that seeing less gray matter so early was so novel that it should be treated cautiously unless other studies find a similar result.

In the second study, brain imaging was used to look for amyloid plaques in 50 people ages 20 to 56: 11 with dementia, 19 mutation carriers without symptoms and 20 normal family members. Plaques occurred at an average age of 28, more than 15 years before cognitive impairment would be expected and two decades before dementia.

The study also found that amyloid plaques increased steadily until about age 37, after which the brain did not seem to gain many more plaques. Dr. Blennow said that while researchers know that amyloid plaques plateau when people already have dementia, they did not know that the plateau appears to occur years before.

The researchers are currently analyzing data from family members ages 7 to 17 to see if some of the brain changes occur at an even younger age.

“Some people think that that may be scary, that you can see it so many years before,” Dr. Reiman said. “But it seems to me that that provides potential opportunities for the development of future therapies.”

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Bruce Bent Sr. and Son Cleared of Fraud Charges

Regulators failed Monday to win a clear victory over the father-and-son team whose mutual fund failed in one of the signal events of the 2008 financial crisis. It was the latest setback in efforts by regulators to hold individuals responsible for the risk-taking that nearly brought down the American economy.

Louis Lanzano/Associated Press

Bruce Bent, right, and his son, Bruce Bent II, in October. The two were accused of defrauding investors when their flagship money market fund collapsed in September 2008.

Andrew Kelly/Reuters

Bruce Bent is credited with inventing a popular type of mutual fund.

A Manhattan federal jury rejected claims by the Securities and Exchange Commission that Bruce Bent, the inventor of a popular investment vehicle called a money market fund, defrauded investors when his flagship fund collapsed in September 2008, sowing panic among ordinary investors.

The collapse was a turning point because the fund, the Reserve Primary Fund, run by Mr. Bent and his son, Bruce Bent II, was pitched to investors as a nearly risk-free alternative to a bank account. The fund ended up foundering under the weight of hundreds of millions of dollars of bonds issued by Lehman Brothers that became worthless with Lehman’s bankruptcy on Sept. 15, 2008.

The S.E.C.’s lawyers accused the men of misleading investors and the company’s trustees as the fund’s investments fell below a net asset value of $1 per share, an event known as “breaking the buck.” That guaranteed value had been the symbol to investors that they could recover every dollar they invested in such a fund.

The agency accused the pair in a 2009 civil suit of falsely providing assurances that they would plow money into the faltering fund. In fact, the agency contended, both men “secretly harbored” concerns that they could not shore up the fund and keep it from insolvency.

The jury’s decision to clear Mr. Bent and his son on civil fraud charges underscores the difficulty that prosecutors and regulators have had in going after the big bets taken by various individuals and major financial institutions in the years leading up to the financial crisis.

The gulf in prosecutions against individuals is a stark departure from the prosecutions secured after the failure of savings and loan institutions in the late 1980s, after which more than 800 bank officials went to jail. In the wake of the latest crisis, law enforcement officials have failed to secure any high-profile courtroom victories.

“The agency has lost again because they haven’t been able to secure an individual conviction, even in this banner case,” said William K. Black, a professor of law at University of Missouri, Kansas City, and the federal government’s director of litigation during the savings and loan crisis.

The jurors did find the younger Mr. Bent negligent, and two entities associated with the fund were found liable on some counts of fraud.

Robert Khuzami, the S.E.C.’s director of enforcement, emphasized the points on which the commission’s case was affirmed.

“Today’s verdict of liability sends the message that fund executives cannot withhold from investors and trustees key information about their fund’s vulnerability,” he said. “This case, along with our actions against more than 100 other entities and individuals, demonstrates our continuing commitment to pursuing cases arising out of the financial crisis.”

But critics of the agency said Monday’s decision was still a defeat.

Thomas Gorman,  a partner at Dorsey & Whitney and formerly the senior counsel for the S.E.C.’s Division of Enforcement, noted that even with the negligence finding, “the complaint charged them with intentional fraud and went to great length to detail that, and the jury rejected those charges in each instance.”

Monday’s verdict came as regulators are still battling over rules to govern the money market fund industry.

In testimony at the trial, the elder Mr. Bent struck an unapologetic tone. “I thought Lehman was a good, worthwhile investment,” he said, adding in his testimony that the S.E.C. had made the same determination.

Mr. Bent’s fund had plowed roughly $785 million into the Lehman Brothers’ debt. That decision proved fatal when Lehman filed for bankruptcy and the debt, which made up about 1 percent of the fund’s assets, was suddenly worthless.

In the S.E.C.’s case, the agency accused the Bents of deceiving investors. Despite telling investors that they would avert the collapse of the fund by putting more money in, the agency alleged, the Bents never really had any intention of doing that.

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Changing of the Guard: Chinese Communist Party Faces Calls for Democracy

BEIJING — As the Communist Party’s 18th Congress approached, Li Weidong, a scholar of politics, made plans to observe a historic leadership battle in one of the world’s great nations.

Instead of staying in Beijing to monitor China’s once-a-decade transfer of power, Mr. Li boarded a plane.

“I’m going to the United States to study the elections,” Mr. Li said in a telephone interview during a stopover in Paris. After witnessing the American presidential election on Tuesday, Mr. Li went on the radio for another interview. “I still think China’s politics remain prehistoric,” he said. “I often joke that the Chinese civilization is the last prehistoric civilization left in the world.”

With China at a critical juncture, there is a rising chorus within the elite expressing doubt that the 91-year-old Communist Party’s authoritarian system can deal with the stresses bearing down on the nation and its 1.3 billion people. Policies introduced after 1978 by Deng Xiaoping lifted hundreds of millions out of poverty and transformed the country into the world’s second-largest economy. But the way party leaders have managed decades of growth has created towering problems that critics say can no longer be avoided.

Many of those critics have benefited from China’s stunning economic gains, and their ranks include billionaires, intellectuals and children of the party’s revolutionary founders. But they say the party’s agenda, as it stands today, is not visionary enough to set China on the path to stability. What is needed, they say, is a comprehensive strategy to gradually extricate the Communist Party, which has more than 80 million members, from its heavy-handed control of the economy, the courts, the news media, the military, educational institutions, civic life and just the plain day-to-day affairs of citizens.

Only then, the critics argue, can the government start to address the array of issues facing China, including rampant corruption, environmental degradation, and an aging population whose demographics have been skewed because of the one-child policy.

“In order to build a real market economy, we have to have real political reform,” said Yang Jisheng, a veteran journalist and a leading historian of the Mao era. “In the next years, we should have a constitutional democracy plus a market economy.”

For now, however, party leaders have given no indication that they intend to curb their role in government in a meaningful way.

“We will never copy a Western political system,” Hu Jintao, the departing party chief, said in a speech on Thursday opening the weeklong congress.

The party’s public agenda, which Mr. Hu described in detail in his 100-minute address, was laid out in a 64-page report that is in part intended to highlight priorities for the new leaders, who will be announced later this month. Much of the document had retrograde language that emphasized ideology stretching back to Mao and had little in the way of bold or creative thinking, said Qian Gang, the director of the China Media Project at the University of Hong Kong.

Most telling, there was no language signaling that the incoming Politburo Standing Committee, the group that rules China by consensus, would support major changes in the political system, whose perversions many now say are driving the nation toward crisis.

While Chinese who are critical of the current system generally do not expect a wholesale adoption of a Western model, they do favor at least an openness to bolder experimentation.

“To break one-party rule right now is probably not realistic, but we can have factions within the party made public and legalized, so they can campaign against each other,” said Mr. Yang, who added that there was no other way at the moment to ensure political accountability.

Only in the last few years has the idea of liberalizing the political system gained currency, and urgency, among a broad cross-section of elites. Before that, as the West foundered at the onset of the global financial crisis, many here pointed to the triumph of a “China model” or “Beijing consensus” — a mix of authoritarian politics, a command economy and quasi-market policies.

But the way in which China weathered the crisis — with the injection of $588 billion of stimulus money into the economy and an explosion of lending from state banks — led to a spate of large infrastructure projects that may never justify their cost. As a result, many economists now say that China’s investment-driven, export-oriented economic model is unsustainable and needs to shift toward greater reliance on Chinese consumers.

Constant lip-service is paid to that goal, and on Saturday, Zhang Ping, a senior official, reiterated that stance. But it will not be easy for the new leaders to carry it out. At the root of the current economic model is the political system, in which party officials and state-owned enterprises work closely together, reaping enormous profits from the party’s control of the economy. Under Mr. Hu’s decade-long tenure, these relationships and the dominance of state enterprises have only strengthened.

“What happens in this kind of economy is that wealth concentrates where power is,” said Mr. Yang, the journalist.

The 400 or so incoming members of the party’s Central Committee, Politburo and Politburo Standing Committee, as well as their friends and families, have close ties to the most powerful of China’s 145,000 state-owned enterprises. The growing presence of princelings — the children of notable Communist officials — in the party, the government and corporations could mean an even more closely meshed web of nepotism. It is a system that Xi Jinping, anointed to be the next party chief and president and himself a member of the “red nobility,” would find hard to unravel, even if he wanted to.

Mia Li contributed research.

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Malaysian charged with Facebook insult of sultan; sister says he’ll file police complaint

KUALA LUMPUR, Malaysia – The sister of a Malaysian man who has been charged with insulting a state sultan on Facebook says he is innocent and plans to lodge a complaint over his detention.

Anisa Abdul Jalil, sister of Ahmad Abdul Jalil, says her brother was charged Thursday with making offensive postings on Facebook last month.

She says the charges are ridiculous because there is no evidence linking Ahmad to the posts in question, which were made by someone using the name “Zul Yahaya.”

Ahmad was freed on bail Thursday after six days of detention. Anisa says he will file a complaint with police for unlawful detention and intimidation.

Nine Malaysian states have sultans and other royal figures. Though their roles are largely ceremonial, acts provoking hatred against them are considered seditious.

Social Media News Headlines – Yahoo! News

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Wild race blows championship open for Keselowski

AVONDALE, Ariz. (AP) — A chaotic race at Phoenix blew NASCAR's championship fight wide open Sunday, moving Brad Keselowski to the brink of a first Sprint Cup title for himself and team owner Roger Penske.

Keselowski heads into next week's season finale with a 20-point lead over five-time NASCAR champion Jimmie Johnson. His car was better than Johnson's, but he capitalized when a tire failure caused Johnson to crash hard and finish 32nd.

But that was the least of the drama.

Kevin Harvick snapped a 44-race losing streak in a crash-marred finish, and the crews for Jeff Gordon and Clint Bowyer brawled in the garage after Gordon intentionally wrecked Bowyer on the track.

It led to a meeting between the drivers and crew chiefs in the NASCAR hauler with police officers standing guard outside.

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Mind Faded, Darrell Royal’s Wisdom and Humor Intact Till End

Three days before his death last week at 88, Darrell Royal told his wife, Edith: “We need to go back to Hollis” — in Oklahoma. “Uncle Otis died.”

“Oh, Darrell,” she said, “Uncle Otis didn’t die.”

Royal, a former University of Texas football coach, chuckled and said, “Well, Uncle Otis will be glad to hear that.”

The Royal humor never faded, even as he sank deeper into Alzheimer’s disease. The last three years, I came to understand this as well as anyone. We had known each other for more than 40 years. In the 1970s, Royal was a virile, driven, demanding man with a chip on his shoulder bigger than Bevo, the Longhorns mascot. He rarely raised his voice to players. “But we were scared to death of him,” the former quarterback Bill Bradley said.

Royal won 3 national championships and 167 games before retiring at 52. He was a giant in college football, having stood shoulder to shoulder with the Alabama coach Bear Bryant. Royal’s Longhorns defeated one of Bryant’s greatest teams, with Joe Namath at quarterback, in the 1965 Orange Bowl. Royal went 3-0-1 in games against Bryant.

Royal and I were reunited in the spring of 2010. I barely recognized him. The swagger was gone. His mind had faded. Often he stared aimlessly across the room. I scheduled an interview with him for my book “Courage Beyond the Game: The Freddie Steinmark Story.” Still, I worried that his withering mind could no longer conjure up images of Steinmark, the undersize safety who started 21 straight winning games for the Longhorns in the late 1960s. Steinmark later developed bone cancer that robbed him of his left leg.

When I met with Royal and his wife, I quickly learned that his long-term memory was as clear as a church bell. For two hours, Royal took me back to Steinmark’s recruiting trip to Austin in 1967, through the Big Shootout against Arkansas in 1969, to the moment President Richard M. Nixon handed him the national championship trophy in the cramped locker room in Fayetteville. He recalled the day at M. D. Anderson Hospital in Houston the next week when doctors informed Steinmark that his leg would be amputated if a biopsy revealed cancer. Royal never forgot the determined expression on Steinmark’s face, nor the bravery in his heart.

The next morning, Royal paced the crowded waiting room floor and said: “This just can’t be happening to a good kid like Freddie Steinmark. This just can’t be happening.”

With the love of his coach, Steinmark rose to meet the misfortune. Nineteen days after the amputation, he stood with crutches on the sideline at the Cotton Bowl for the Notre Dame game. After the Longhorns defeated the Fighting Irish, Royal tearfully presented the game ball to Steinmark.

Four decades later, while researching the Steinmark book, I became close to Royal again. As I was leaving his condominium the day of the interview, I said, “Coach, do you still remember me?” He smiled and said, “Now, Jim Dent, how could I ever forget you?” My sense of self-importance lasted about three seconds. Royal chuckled. He pointed across the room to the message board next to the front door that read, “Jim Dent appt. at 10 a.m.”

Edith and his assistant, Colleen Kieke, read parts of my book to him. One day, Royal told me, “It’s really a great book.” But I can’t be certain how much he knew of the story.

Like others, I was troubled to see Royal’s memory loss. He didn’t speak for long stretches. He smiled and posed for photographs. He seemed the happiest around his former players. He would call his longtime friend Tom Campbell, an all-Southwest Conference defensive back from the 1960s, and say, “What are you up to?” That always meant, “Let’s go drink a beer.”

As her husband’s memory wore thin, Edith did not hide him. Instead, she organized his 85th birthday party and invited all of his former players. Quarterback James Street, who engineered the famous 15-14 comeback against Arkansas in 1969, sat by Royal’s side and helped him remember faces and names. The players hugged their coach, then turned away to hide the tears.

In the spring of 2010, I was invited to the annual Mexican lunch for Royal attended by about 75 of his former players. A handful of them were designated to stand up and tell Royal what he meant to them. Royal smiled through each speech as his eyes twinkled. I was mesmerized by a story the former defensive tackle Jerrel Bolton told. He recalled that Royal had supported him after the murder of his wife some 30 year earlier.

“Coach, you told me it was like a big cut on my arm, that the scab would heal, but that the wound would always come back,” Bolton said. “It always did.”

Royal seemed to drink it all in. But everyone knew his mind would soon dim.

The last time I saw him was June 20 at the County Line, a barbecue restaurant next to Bull Creek in Austin. Because Royal hated wheelchairs and walkers, the former Longhorn Mike Campbell, Tom’s twin, and I helped him down the stairs by wrapping our arms around his waist and gripping the back of his belt. I ordered his lunch, fed him his sandwich and cleaned his face with a napkin. He looked at me and said, “Was I a college player in the 1960s?”

“No, Coach,” I said. “But you were a great player for the Oklahoma Sooners in the late 1940s. You quarterbacked Oklahoma to an 11-0 record and the Sooners’ first national championship in 1949.”

He smiled and said, “Well, I’ll be doggone.”

After lunch, Mike Campbell and I carried him up the stairs. We sat him on a bench outside as Tom Campbell fetched the car. In that moment, the lunch crowd began to spill out of the restaurant. About 20 customers recognized Royal. They took his photograph with camera phones. Royal smiled and welcomed the hugs.

“He didn’t remember a thing about it,” Tom Campbell said later. “But it did his heart a whole lot of good.”

Jim Dent is the author of “The Junction Boys” and eight other books.

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Hurricane Sandy and the Disaster-Preparedness Economy

Jeffrey Phelps for The New York Times

An assembly line at a Generac Power Systems plant. Generac makes residential generators, coveted items in the wake of Hurricane Sandy.

FOLKS here don’t wish disaster on their fellow Americans. They didn’t pray for Hurricane Sandy to come grinding up the East Coast, tearing lives apart and plunging millions into darkness.

But the fact is, disasters are good business in Waukesha. And, lately, there have been a lot of disasters.

This Milwaukee suburb, once known for its curative spring waters and, more recently, for being a Republican stronghold in a state that President Obama won on Election Day, happens to be the home of one of the largest makers of residential generators in the country. So when the lights go out in New York — or on the storm-savaged Jersey Shore or in tornado-hit Missouri or wherever — the orders come pouring in like a tidal surge.

It’s all part of what you might call the Mad Max Economy, a multibillion-dollar-a-year collection of industries that thrive when things get really, really bad. Weather radios, kerosene heaters, D batteries, candles, industrial fans for drying soggy homes — all are scarce and coveted in the gloomy aftermath of Hurricane Sandy and her ilk.

It didn’t start with the last few hurricanes, either. Modern Mad Max capitalism has been around a while, decades even, growing out of something like old-fashioned self-reliance, political beliefs and post-Apocalyptic visions. The cold war may have been the start, when schoolchildren dove under desks and ordinary citizens dug bomb shelters out back. But economic fears, as well as worries about climate change and an unreliable electronic grid have all fed it.

 Driven of late by freakish storms, this industry is growing fast, well beyond the fringe groups that first embraced it. And by some measures, it’s bigger than ever.

Businesses like Generac Power Systems, one of three companies in Wisconsin turning out generators, are just the start.

The market for gasoline cans, for example, was flat for years. No longer. “Demand for gas cans is phenomenal, to the point where we can’t keep up with demand,” says Phil Monckton, vice president for sales and marketing at Scepter, a manufacturer based in Scarborough, Ontario. “There was inventory built up, but it is long gone.”

Even now, nearly two weeks after the superstorm made landfall in New Jersey, batteries are a hot commodity in the New York area. Win Sakdinan, a spokesman for Duracell, says that when the company gave away D batteries in the Rockaways, a particularly hard-hit area, people “held them in their hands like they were gold.”

Sales of Eton emergency radios and flashlights rose 15 percent in the week before Hurricane Sandy — and 220 percent the week of the storm, says Kiersten Moffatt, a company spokeswoman. “It’s important to note that we not only see lifts in the specific regions affected, we see a lift nationwide,” she wrote in an e-mail. “We’ve seen that mindfulness motivates consumers all over the country to be prepared in the case of a similar event.”

Garo Arabian, director of operations at B-Air, a manufacturer based in Azusa, Calif., says he has sold thousands of industrial fans since the storm. “Our marketing and graphic designer is from Syria, and he says: ‘I don’t understand. In Syria, we open the windows.’ ”

But Mr. Arabian says contractors and many insurers know that mold spores won’t grow if carpeting or drywall can be dried out within 72 hours. “The industry has grown,” he says, “because there is more awareness about this kind of thing.”

Retailers that managed to stay open benefited, too. Steve Rinker, who oversees 11 Lowe’s home improvement stores in New York and New Jersey, says his stores were sometimes among the few open in a sea of retail businesses.

Predictably, emergency supplies like flashlights, lanterns, batteries and sump pumps sold out quickly, even when they were replenished. The one sought-after item that surprised him the most? Holiday candles. “If anyone is looking for holiday candles, they are sold out,” he says. “People bought every holiday candle we have during the storm.”

If the hurricane was a windfall for Lowe’s, its customers didn’t seem to mind. Rather, most appeared exceedingly grateful when Mr. Rinker, working at a store in Paterson, N.J., pointed them toward a space heater, or a gasoline can, that could lessen the misery of another day without power.

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David Petraeus, Seen as an Invincible C.I.A. Director, Self-Destructs

Alex Wong/Getty Images

David H. Petraeus, with his wife, Holly, in 2011 during his confirmation hearing in the Senate before becoming director of the Central Intelligence Agency.

WASHINGTON — David H. Petraeus’s “Rules for Living” appeared on The Daily Beast Web site on Monday, posted by his biographer, a fellow West Point graduate 20 years his junior named Paula Broadwell. The fifth rule, beneath his familiar portrait in full military regalia, began: “We all make mistakes. The key is to recognize them and admit them.”

Mr. Petraeus took his own advice on Friday and resigned as director of the Central Intelligence Agency after admitting to an extramarital affair; officials identified the woman in question as Ms. Broadwell. The full back story is not yet clear, though his affair came to light after F.B.I. agents conducting a criminal investigation into possible security breaches examined his computer e-mails. The decision to step down was his.

Few imagined that such a dazzling career would have so tawdry and so sudden a collapse. Mr. Petraeus, a slender fitness fanatic, is known as a brainy ascetic. He and his wife, Holly, whose father was the superintendent at West Point when Mr. Petraeus graduated in 1974, and their two grown children had long been viewed by military families as an inspiration, a model for making a marriage work despite the separation and hardship of long deployments overseas.

After he began the C.I.A. job in September 2011, the couple settled into a house in the Virginia suburbs and began the closest thing to a normal life together that they had had in years, even if the basement he had designated for a home gym was commandeered for secure C.I.A. communications gear.

After years in war zones, Mr. Petraeus told friends, he was amazed to eat dinner most nights with his wife and to discover weekends again. He told friends that on the day his daughter was married last month, he went for a 34-mile bike ride.

“It’s a personal tragedy, of course, but it’s also a tragedy for the country,” said Bruce Riedel, a C.I.A. veteran and a presidential adviser.

Like many others in jaundiced Washington, Mr. Riedel wondered whether the affair really required Mr. Petraeus, who turned 60 on Wednesday, to step down and leave the agency leaderless. But under the military law that governed his 37-year Army career, adultery is a crime when it may “bring discredit upon the armed forces.” And a secret affair can make an intelligence officer vulnerable to blackmail.

The C.I.A. director, Mr. Riedel said, probably felt he had no choice.

“I think Dave Petraeus grew up with a code that’s very demanding about duty and honor,” he said. “He violated the code.”

Ambition and Ability

He was the pre-eminent military officer of his generation, a soldier-scholar blazing with ambition and intellect, completing his meteoric rise as a commander in the Iraq and Afghanistan wars. Worshipful Congressional committees lauded him as a miracle worker for helping turn the war in Iraq around, applying a counterinsurgency strategy he had helped devise and that was widely viewed for a time as the future of warfare. Then, dispatched to Afghanistan to replace Gen. Stanley A. McChrystal, who had been fired by President Obama, he sought to apply the doctrine he had championed, while also applying an aggressive counterterrorism strategy. 

He was fiercely competitive and carefully protective of his reputation. Asked to throw out the first pitch at the 2008 World Series, he brought his security detail to Washington’s stadium to practice getting the ball over the plate.

Mr. Petraeus had seemed all but indestructible. He had been shot in a training accident, had broken his pelvis in a sky diving mishap and survived prostate cancer. Criticized by the advocacy group MoveOn.org in 2007 as “General Betray Us,” he shrugged off the attack and rallied his indignant supporters. Until Friday, fans speculated that post-C.I.A. he might become president of Princeton University, where he had earned his Ph.D. in international relations in 1987, or conceivably even president of the United States. (He has told friends he will never run for president; to show his impartiality, while in the military, he did not vote.)

Reporting was contributed by Thom Shanker, Michael R. Gordon and David E. Sanger from Washington, and Viv Bernstein from Charlotte, N.C.

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Review: iPad Mini charms, but screen is a letdown

NEW YORK (AP) — I bet the iPad Mini is going to be on a lot of wish lists this holiday season. I also bet that for a lot of people, it’s not going to be the best choice. It’s beautiful and light, but Apple made a big compromise in the design, one that means that buyers should look closely at the competition before deciding.

Starting at $ 329, the iPad Mini is the cheapest iPad. The screen is a third smaller than the regular iPads, and it sits in an exquisitely machined aluminum body. It weighs just 11 ounces — half as much as a full-size iPad — making it easier to hold in one hand. It’s just under 8 inches long and less than a third of an inch thick, so it fits easily into a handbag.

The issue is the screen quality. Apple has been on the forefront of a move toward sharper, more colorful screens. It calls them “Retina” displays because the pixels — the little light-emitting squares that make up the screen — are so small that they blend together almost seamlessly in our eyes, removing the impression that we’re watching a grid of discrete elements.

The iPad Mini doesn’t have a Retina screen. By the standards of last year, it’s a good screen, with the same number of pixels as the first iPad and the iPad 2. The latest full-size iPad has four times as many pixels, and it really shows. By comparison, the iPad Mini’s screen looks coarse. It looks dull, too, because it doesn’t have the same color-boosting technology that the full-size model has.

This is not an entirely fair comparison, as the full-size iPad starts at $ 499 and weighs twice as much. The real issue is that this year, there are other tablets that are cheaper than the iPad Mini, weigh only slightly more and still have better screens.

Amazon.com Inc.’s Kindle Fire HD costs $ 199 and has about the same overall size as the Mini. While the Kindle’s screen is somewhat smaller (leaving a bigger frame around the edges), it is also sharper, with 30 percent more pixels than the Mini. Colors are slightly brighter, too.

Barnes & Noble Inc.’s Nook HD costs $ 229 for a comparable model with 16 gigabytes of storage and has a screen that’s even sharper than the Kindle HD’s. It’s got 65 percent more pixels than the iPad Mini. (There’s a $ 199 model with half the memory, and the storage space can be expanded with inexpensive memory cards.)

Why do tablets from two companies chiefly known as book stores beat Apple’s latest for screen quality?

Sharper screens are darker, requiring a more powerful backlight to appear bright. That, in turn, would have forced an increase in the battery size. That’s the reason the first iPad with a Retina display was thicker and heavier than the iPad 2. So to keep the iPad Mini thin while matching the 10-hour battery life of the bigger iPads, Apple had to compromise on the display.

This can’t last, though. By next year, it will likely be even more obvious that Apple is seriously behind in screen quality on its small tablet, and it will have to upgrade to a Retina display somehow. That means this first-generation iPad Mini will look old pretty fast.

The display causes a few other problems, too. One is that when you run iPhone apps on the Mini, it uses the coarsest version of the graphics for that app — the version designed for iPhones up to the 2009 model, the 3GS. You can blow the app up to fill more of the screen, but it looks pretty ugly. The full-size iPad uses the higher-quality Retina graphics when running iPhone apps, and it looks much better.

Some apps adapted for the iPad screen don’t display that well on the Mini screen, either, because of the smaller size. Buttons can be too small to hit accurately, bringing to mind Steve Jobs’ 2010 comments about smaller tablets. The late Apple founder was of the vociferous opinion that the regular iPad was the smallest size that was also friendly to use.

In some apps, text on the Mini is too small to be comfortably read — the section fronts in The New York Times and The Wall Street Journal apps are examples of this.

Of course, in some other respects, the iPad Mini outdoes the Fire and the Nook, so it isn’t just the tablet for the buyer who needs the prettiest and the thinnest. In particular, the Mini is a $ 329 entry ticket to the wonderful world of iPad and iPhone apps. For quality and quantity, it beats all the other app stores. (Oddly, there’s an inverse relationship between screen quality and app availability in this category — the Nook HD has the best screen and the fewest apps, while the second-best Kindle Fire HD has middling access to apps.)

The Mini also has front- and back-facing cameras, for taking still photos and video and for videoconferencing. The Kindle Fire HD only has a front-facing camera for videoconferencing. The Nook HD doesn’t have a camera at all.

In short, the iPad Mini is more versatile than the competition, and I’m sure it will please a lot of people. But take a look at the competition first, and figure that by next year, we’ll see something from Apple that looks a lot better.

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Peter Svensson can be reached at http://twitter.com/petersvensson

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About the iPad Mini:

The base model of the iPad Mini costs $ 329 and comes with 16 gigabytes of storage. A 32 GB model goes for $ 429 and 64 GB for $ 529. Soon, you’ll be able to get versions that can connect through cellular networks, not just Wi-Fi. Add $ 130 to the price.

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Manziel, No. 15 Texas A&M stun No. 1 Bama, 29-24

TUSCALOOSA, Ala. (AP) — Johnny Manziel and No. 15 Texas A&M shook up the national championship race by beating No. 1 Alabama 29-24 on Saturday.

The Aggies (8-2, 5-2), playing in the Southeastern Conference for the first season, also might have ended the league's run of BCS titles at six years.

The Crimson Tide (9-1, 6-1) didn't go quietly.

AJ McCarron nearly pulled off a second straight scintillating comeback. He threw one touchdown pass and motored the ball downfield before Deshazor Everett stepped in front of his fourth-down pass at the goal line with 1:36 left.

Manziel passed for 253 yards and rushed for 92 and led the Aggies to a 20-0 first quarter lead.

"No moment is too big for him," coach Kevin Sumlin said of his remarkable redshirt freshman.

Alabama kept coming back, but never caught up with Manziel and Texas A&M.

Alabama, the nation's top scoring defense, forced a punt with less than a minute left, but A&M never had to kick it waway. The Tide was penalized for offisides, giving Texas A&M a first down and a chance to kneel out the clock.

McCarron breathed life into Alabama with a 54-yard touchdown pass down the left sideline to freshman Amari Cooper to make it 29-24 with 4:29 left.

A quick three-and-out by the Aggies put the ball in McCarron's hands again. He opened at the 40 with a 54-yarder to speedster Kenny Bell down to the 6. Two scrambles and an Eddy Lacy run left one final shot from the 2 against a Texas A&M defense often overshadowed by its potent offense.

McCarron had rescued the Tide's national title hopes with a 28-yard screen pass in the final minute for a 21-17 win over No. 9 LSU. The Aggies, nearly two-touchdown underdogs, didn't let him do it again. Everett made the play on a pass toward the front corner of the end zone.

The Aggies had already lost to top-10 teams LSU and Florida by a combined eight points, proving they're already challengers in the powerhouse SEC.

Alabama managed a second-shot national title after losing to LSU just over a year ago in the regular season but seems a longshot to do it again. Alabama would have secured a spot in the SEC championship game with a victory and only Western Carolina and Auburn remaining.

Now, the Tide will have to beat the Tigers to clinch the West and get into the SEC title game. As for the national title, Alabama will have to hope for another shakeup in the form of losses by Kansas State, Oregon and Notre Dame. If the Tide wins out, and two of those teams go down, a third national championship in four seasons is still in play — along with a seventh straight for the SEC.

For now though, the SEC is on the outside looking in at the BCS title race.

Manziel picked apart and bedeviled the nation's top scoring defense. He completed 24 of 31 passes with two touchdowns and ran 18 times, leading three first-quarter touchdown drives to stun the Bryant-Denny Stadium crowd.

The rest of the game was an emotional roller-coaster ride for fans who might have though LSU was the toughest test on the road to another championship.

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